Germany: PhD in Morphogenesis-EMBL Heidelberg
PhD in Systems Biology
Morphogenesis in Fission Yeast
European Molecular Biology Laboratory, Heidelberg, Germany.
The fission yeast Schizosaccharomyces pombe maintains a cylindrical
shape by alternating polarized growth at the cell ends with divisions
in the middle. The localized growth is established during interphase
by bundles of microtubules that deposit growth factors specifically at
cell ends. The bundles are also attached to the nucleus, keeping it
near the cell-center. This is because bundles are anti-parallel, align
along the main cell axis and transmit the microtubule polymerization
forces from both sides to the nucleus. We have modelled the nucleus
and microtubules with simulated Langevin dynamics in three dimensions.
We could match most of the experimentally measured microtubule
features, using a fix cylindrical cell shape.
We propose now to study how S. pombe determines its shape. The student
will have to extend the existing model to include abitrary convex
shapes. He/her will have to model the transport and deposition of
growth factors by the microtubules, and their effects on cell growth.
The work will be done in collaboration with Damian Brunner (EMBL).
Together, we will test the model using fluorescence recordings of both
wild type and mutant cells followed on multiple generations. The
proposed work is a systems' level approach of morphogenesis in a
simple cell, and the student will combine experiments and theory
during his/her PhD.
Applicants with prior training in Physics, Mathematics, I.T. or
engineering, and a willingness to explore the opportunities offered in
Biology are encouraged to apply. EMBL is a renowned international
research laboratory, with more than 60 nationalities represented. The
working language is English.
The deadline for application is November 1st, 2006.
To apply online: www.embl.de/training/phdprogramme
Important: select Cell Biology and Biophysics in your `Programme
preference'
For more information: www.cytosim.org
François Nédélec, BioMS Group leader
EMBL, Cell Biology and Cell Biophysics
Meyerhofstrasse 1, 69117 Heidelberg, Germany
Email: nedelec@embl.de
Telephone: (+49) 6221 387 597
Telefax: (+49) 6221 387 512
-------------------------------------------------
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Morphogenesis in Fission Yeast
European Molecular Biology Laboratory, Heidelberg, Germany.
The fission yeast Schizosaccharomyces pombe maintains a cylindrical
shape by alternating polarized growth at the cell ends with divisions
in the middle. The localized growth is established during interphase
by bundles of microtubules that deposit growth factors specifically at
cell ends. The bundles are also attached to the nucleus, keeping it
near the cell-center. This is because bundles are anti-parallel, align
along the main cell axis and transmit the microtubule polymerization
forces from both sides to the nucleus. We have modelled the nucleus
and microtubules with simulated Langevin dynamics in three dimensions.
We could match most of the experimentally measured microtubule
features, using a fix cylindrical cell shape.
We propose now to study how S. pombe determines its shape. The student
will have to extend the existing model to include abitrary convex
shapes. He/her will have to model the transport and deposition of
growth factors by the microtubules, and their effects on cell growth.
The work will be done in collaboration with Damian Brunner (EMBL).
Together, we will test the model using fluorescence recordings of both
wild type and mutant cells followed on multiple generations. The
proposed work is a systems' level approach of morphogenesis in a
simple cell, and the student will combine experiments and theory
during his/her PhD.
Applicants with prior training in Physics, Mathematics, I.T. or
engineering, and a willingness to explore the opportunities offered in
Biology are encouraged to apply. EMBL is a renowned international
research laboratory, with more than 60 nationalities represented. The
working language is English.
The deadline for application is November 1st, 2006.
To apply online: www.embl.de/training/phdprogramme
Important: select Cell Biology and Biophysics in your `Programme
preference'
For more information: www.cytosim.org
François Nédélec, BioMS Group leader
EMBL, Cell Biology and Cell Biophysics
Meyerhofstrasse 1, 69117 Heidelberg, Germany
Email: nedelec@embl.de
Telephone: (+49) 6221 387 597
Telefax: (+49) 6221 387 512
-------------------------------------------------
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